An ACTH-(4–9) analogue, Org 2766, improves recovery from acrylamide neuropathy in rats
| Autor: | Willem Hendrik Gispen, Roland Gerritsen van der Hoop, Philippa M. Edwards, R.Emine Sporel-Özakat |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Nervous system
medicine.medical_specialty Peptide hormone Synaptic Transmission Nerve conduction velocity chemistry.chemical_compound Adrenocorticotropic Hormone Internal medicine Diabetes mellitus medicine Animals Postural Balance Motor Neurons Pharmacology Acrylamides Rats Inbred Strains medicine.disease Peptide Fragments Rats Motor coordination Electrophysiology medicine.anatomical_structure Endocrinology Peripheral neuropathy chemistry Acrylamide Peripheral nervous system Anticonvulsants Female Nervous System Diseases Psychomotor Performance |
| Zdroj: | European Journal of Pharmacology. 186:181-187 |
| ISSN: | 0014-2999 |
| Popis: | Org 2766 is one of a series of melanocortis (ACTH and related peptides) that exert trophic influences on the central and peripheral nervous system of the rat. We used acrylamide neuropathy in rats as an experimental model of peripheral neuropathies of the dying-back type in order to assess the potential therapeutic efficacy of Org 2766 in this type of nerve damage. The peptide reversed the delayed persistent deficit in sensory conduction velocity without preventing the initial loss of motor coordination. The recovery of apparently normal coordination was unaffected by the peptide, but resistance to a second toxic challenge suggested that recovery was more complete in the peptide-treated rats. The finding that Org 2766 improved the quality of the repair following acrylamide neuropathy, together with previous studies showing beneficial effects in neuropathies caused by cisplatin or diabetes and after mechanical trauma, strongly suggests that Org 2766 may be beneficial in the treatment of various conditions in which the nervous system has sustained damage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|