Investigating genetic links between grapheme-colour synaesthesia and neuropsychiatric traits

Autor: Anton V. Sidoroff-Dorso, Joery den Hoed, Duncan Carmichael, Jamie Ward, Beate St Pourcain, Simon E. Fisher, Loes van den Heuvel, Julia Simner, Arianna Vino, Amanda K. Tilot, Romke Rouw, Archie Campbell, Tessa M. van Leeuwen, David J. Porteous, Katerina S. Kucera
Přispěvatelé: Brein en Cognitie (Psychologie, FMG), Language, Communication and Cognition
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Neuroinformatics
Male
Multifactorial Inheritance
Adolescent
media_common.quotation_subject
autism
Neuropsychological Tests
General Biochemistry
Genetics and Molecular Biology
synaesthesia/synesthesia
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Memory
Synesthesia/genetics
Perception
medicine
Humans
Preschool
Association (psychology)
Child
030304 developmental biology
media_common
2. Zero hunger
0303 health sciences
Action
intention
and motor control
Neuropsychology
medicine.disease
Autism Spectrum Disorder/genetics
schizophrenia
polygenic scores
Autism spectrum disorder
Schizophrenia
Child
Preschool
Trait
Imagination
Autism
Female
General Agricultural and Biological Sciences
Psychology
Generation Scotland
030217 neurology & neurosurgery
Color Perception
Clinical psychology
Mental image
Zdroj: Tilot, A K, Vino, A, Kucera, K S, Carmichael, D A, van den Heuvel, L, den Hoed, J, Sidoroff-Dorso, A V, Campbell, A, Porteous, D J, St Pourcain, B, van Leeuwen, T M, Ward, J, Rouw, R, Simner, J & Fisher, S E 2019, ' Investigating genetic links between grapheme-colour synaesthesia and neuropsychiatric traits ', Philosophical Transactions B: Biological Sciences, vol. 374, no. 1787 . https://doi.org/10.1098/rstb.2019.0026
Philosophical Transactions of the Royal Society B-Biological Sciences, 374(1787):20190026. Royal Society of London
Philosophical Transactions of the Royal Society B: Biological Sciences, 374(1787), 1-11. ROYAL SOC
Philosophical Transactions-Royal Society. Biological Sciences, 374, 1-11
Tilot, A K, Vino, A, Kucera, K S, Carmichael, D A, van den Heuvel, L, den Hoed, J, Sidoroff-Dorso, A V, Campbell, A, Porteous, D J, St Pourcain, B, van Leeuwen, T M, Ward, J, Rouw, R, Simner, J & Fisher, S E 2019, ' Investigating genetic links between grapheme-colour synaesthesia and neuropsychiatric traits ', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 374, no. 1787, pp. 20190026 . https://doi.org/10.1098/rstb.2019.0026
Philosophical Transactions-Royal Society. Biological Sciences, 374, 1787, pp. 1-11
Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences
ISSN: 0962-8436
Popis: Synaesthesia is a neurological phenomenon affecting perception, where triggering stimuli (e.g. letters and numbers) elicit unusual secondary sensory experiences (e.g. colours). Family-based studies point to a role for genetic factors in the development of this trait. However, the contributions of common genomic variation to synaesthesia have not yet been investigated. Here, we present the SynGenes cohort, the largest genotyped collection of unrelated people with grapheme–colour synaesthesia ( n = 723). Synaesthesia has been associated with a range of other neuropsychological traits, including enhanced memory and mental imagery, as well as greater sensory sensitivity. Motivated by the prior literature on putative trait overlaps, we investigated polygenic scores derived from published genome-wide scans of schizophrenia and autism spectrum disorder (ASD), comparing our SynGenes cohort to 2181 non-synaesthetic controls. We found a very slight association between schizophrenia polygenic scores and synaesthesia (Nagelkerke's R 2 = 0.0047, empirical p = 0.0027) and no significant association for scores related to ASD (Nagelkerke's R 2 = 0.00092, empirical p = 0.54) or body mass index ( R 2 = 0.00058, empirical p = 0.60), included as a negative control. As sample sizes for studying common genomic variation continue to increase, genetic investigations of the kind reported here may yield novel insights into the shared biology between synaesthesia and other traits, to complement findings from neuropsychology and brain imaging. This article is part of a discussion meeting issue ‘Bridging senses: novel insights from synaesthesia'.
Databáze: OpenAIRE
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