Effects of hesperidin on anti-inflammatory and antioxidant response in healthy people: a meta-analysis and meta-regression
| Autor: | Yusuf Buzdağlı, Cemre Didem Eyipınar, Fatma Necmiye Kacı, Aslıhan Tekin |
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| Přispěvatelé: | Belirlenecek |
| Rok vydání: | 2022 |
| Předmět: |
Inflammation
Markers Risk antioxidant response Systematic Reviews Consumption Supplementation Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Citrus Flavonoids Expression General Medicine inflammatory markers Pollution Citrus flavanone Flavonoid Hesperidin flavonoids meta-regression Orange Juice Intake |
| Zdroj: | International journal of environmental health research. |
| ISSN: | 1369-1619 |
| Popis: | Hesperidin is a prominent flavanone found in citrus fruits that has a broad range of biological effects, including anti-inflammatory and antioxidant capabilities. The study's objective was to evaluate the effects of hesperidin supplementation on anti-inflammatory and antioxidant parameters such as MDA, TAC, GSH, SOD, and CAT; CRP, TNF-alpha, IL-6, and IL-4 levels respectively, by analyzing human intervention trials. Google Scholar, PubMed, grey literature databases, and the ClinicalTrials website were scanned to identify eligible studies. For the meta-analysis, eighteen studies were chosen. Hesperidin supplementation had significant lowering effect on not only CRP, IL-6, and IL-4 levels but also MDA level (Meta-regression analysis revealed a non-significant direct relationship between hesperidin dosage and chance in CRP, IL-6, and MDA levels. As a result, it can be said that hesperidin supplementation contributes to the inflammatory and antioxidant response, but this contribution is independent of dosage. |
| Databáze: | OpenAIRE |
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