Making sense of astrocytic calcium signals — from acquisition to interpretation
| Autor: | Alexey Semyanov, Christian Henneberger, Amit Agarwal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
chemistry.chemical_element Calcium 03 medical and health sciences 0302 clinical medicine Optical imaging physiology [Brain] Cellular neuroscience ddc:570 Sense (molecular biology) medicine Animals Humans Calcium Signaling Cells Cultured Calcium signaling Neurons Chemistry General Neuroscience Optical Imaging Brain physiology [Astrocytes] physiology [Neurons] 030104 developmental biology Signalling medicine.anatomical_structure Astrocytes physiology [Calcium Signaling] Neuroscience 030217 neurology & neurosurgery Intracellular Astrocyte |
| Zdroj: | Nature reviews / Neuroscience 21(10), 551-564 (2020). doi:10.1038/s41583-020-0361-8 |
| DOI: | 10.1038/s41583-020-0361-8 |
| Popis: | Astrocytes functionally interact with neurons and with other brain cells. Although not electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling that evolves in space and time within single astrocytes and across astrocytic networks. Decoding the physiological meaning of these dynamic changes in astrocytic Ca2+ activity has remained a major challenge. This Review describes experimental preparations and methods for recording and studying Ca2+ activity in astrocytes, focusing on the analysis of Ca2+ signalling events in single astrocytes and in astrocytic networks. The limitations of existing experimental approaches and ongoing technical and conceptual challenges in the interpretation of astrocytic Ca2+ events and their spatio-temporal patterns are also discussed. Although not electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling. Semyanov, Henneberger and Agarwal describe experimental preparations and methods for studying Ca2+ activity in astrocytes, their limitations and the ongoing technical and conceptual challenges in the interpretation of astrocytic Ca2+ events and their spatio-temporal patterns. |
| Databáze: | OpenAIRE |
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