Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging
| Autor: | Lucette Garreau, Johnny Vercouillie, Sylvie Chalon, Denis Guilloteau, Tiziana Raguza, Aina Westrheim Ravna, Patrick Emond, Sylvie Mavel |
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| Rok vydání: | 2008 |
| Předmět: |
Diagnostic Imaging
Benzylamines Fluorine Radioisotopes Molecular model Tertiary amine medicine.drug_class Stereochemistry Clinical Biochemistry Pharmaceutical Science Carboxamide Kidney Ligands Sensitivity and Specificity Biochemistry Chemical synthesis Cell Line Drug Discovery Radioligand medicine Humans Carbon Radioisotopes Molecular Biology Serotonin transporter Serotonin Plasma Membrane Transport Proteins biology Chemistry Organic Chemistry Membrane Transport Proteins Reproducibility of Results Ligand (biochemistry) Docking (molecular) Positron-Emission Tomography biology.protein Molecular Medicine Algorithms |
| Zdroj: | Bioorganic & Medicinal Chemistry. 16:9050-9055 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2008.08.002 |
| Popis: | In order to predict affinity of new diphenylsulfides for the serotonin transporter (SERT), a molecular modeling model was used to compare potential binding affinity of new compounds with known potent ligands. The aim of this study is to identify a suitable PET radioligand for imaging the SERT, new derivatives, and their precursors for a C-11 or F-18 radiolabeling, were synthesized. Two fluorinated derivatives displayed good in vitro affinity for the SERT ( K i = 14.3 ± 1 and 10.1 ± 2.7 nM) and good selectivity toward the other monoamine transporters as predicted by the docking study. |
| Databáze: | OpenAIRE |
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