M2 polarization of monocytes in ankylosing spondylitis and relationship with inflammation and structural damage
| Autor: | Chunsheng Tao, Wei Yuan, Peifeng Sun, Zaixing Yang, Weidong Xu, Jinzhu Zhao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male musculoskeletal diseases 0301 basic medicine Microbiology (medical) medicine.medical_specialty Inflammation Blood Sedimentation Gastroenterology Monocytes Pathology and Forensic Medicine Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Internal medicine CX3CR1 medicine Humans Immunology and Allergy Spondylitis Ankylosing BASDAI 030203 arthritis & rheumatology Ankylosing spondylitis Tumor Necrosis Factor-alpha business.industry CD68 Monocyte General Medicine medicine.disease C-Reactive Protein 030104 developmental biology medicine.anatomical_structure Case-Control Studies Rheumatoid arthritis Immunology Female medicine.symptom business CD163 |
| Zdroj: | APMIS. 125:1070-1075 |
| ISSN: | 0903-4641 |
| DOI: | 10.1111/apm.12757 |
| Popis: | The aim of this study was to evaluate the polarization of peripheral blood monocytes in the patients with ankylosing spondylitis (AS) and to determine the correlations between monocyte polarization and inflammation and structural damage. A total of 120 AS patients, 50 rheumatoid arthritis (RA) patients and 100 healthy controls were enrolled in the study. M1 (CD68+CD192+) and M2 (CX3CR1+CD163+) monocytes were characterized by flow cytometry. Demographic, clinical, radiographic and laboratory data were collected and analyzed. A large increase in M2 (CX3CR1+CD163+) monocytes was observed in AS, and M2/M1 ratio was 7.18 ± 6.12, 2.54 ± 3.14 and 35.61 ± 20.04 in control, RA and AS, respectively. The M2/M1 ratio correlated with modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) (r = 0.565; p |
| Databáze: | OpenAIRE |
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