Genetic and environmental factors in complex neurodevelopmental disorders
| Autor: | G.J.M. Martens, K.M.J. van Loo |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Candidate gene
medicine.medical_specialty media_common.quotation_subject linkage analysis Article 03 medical and health sciences 0302 clinical medicine environmental factors Genetic linkage mental disorders Genetics Medicine susceptibility genes Epigenetics Psychiatry Genetics (clinical) 030304 developmental biology Genetic association media_common 0303 health sciences business.industry Addiction Neurodevelopmental disorders Molecular Animal Physiology gene-environment interactions medicine.disease 3. Good health association studies Schizophrenia Attention deficit Autism business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Current Genomics, 8, 7, pp. 429-444 Current Genomics, 8, 429-444 Current Genomics |
| ISSN: | 1389-2029 |
| Popis: | Complex neurodevelopmental disorders, such as schizophrenia, autism, attention deficit (hyperactivity) disorder, (manic) depressive illness and addiction, are thought to result from an interaction between genetic and environmental factors. Association studies on candidate genes and genome-wide linkage analyses have identified many susceptibility chromosomal regions and genes, but considerable efforts to replicate association have been surprisingly often disappointing. Here, we summarize the current knowledge of the genetic contribution to complex neurodevelopmental disorders, focusing on the findings from association and linkage studies. Furthermore, the contribution of the interaction of the genetic with environmental and epigenetic factors to the aetiology of complex neurodevelopmental disorders as well as suggestions for future research are discussed. |
| Databáze: | OpenAIRE |
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