Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord
| Autor: | S J Hasan, HS Keirstead, Gillian D. Muir, J D Steeves |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pathology
medicine.medical_specialty animal structures Central nervous system Fluorescent Antibody Technique Chick Embryo Nerve Fibers Myelinated Myelin medicine Animals Spinal Cord Injuries Multidisciplinary biology Electromyography Embryogenesis Age Factors Embryo Myelin Basic Protein Anatomy Spinal cord Embryonic stem cell Myelin basic protein Nerve Regeneration Oligodendroglia medicine.anatomical_structure Spinal Cord embryonic structures biology.protein Galactocerebroside Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 89(24) |
| ISSN: | 0027-8424 |
| Popis: | In an embryonic chicken, transection of the thoracic spinal cord prior to embryonic day (E) 13 (of the 21-day developmental period) results in complete neuroanatomical repair and functional locomotor recovery. Conversely, repair rapidly diminishes following a transection on E13-E14 and is nonexistent after an E15 transection. The myelination of fiber tracts within the spinal cord also begins on E13, coincident with the transition from permissive to restrictive repair periods. The onset of myelination can be delayed (dysmyelination) until later in development by the direct injection into the thoracic cord on E9-E12 of a monoclonal antibody to galactocerebroside, plus homologous complement. In such a dysmyelinated embryo, a subsequent transection of the thoracic cord as late as E15 resulted in complete neuroanatomical repair and functional recovery (i.e., extended the permissive period for repair). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|