Effects of anticancer drugs on transcription factor–DNA interactions
Autor: | Marek Gniazdowski, Stephanie M. Nelson, Malgorzata Czyz, William A. Denny |
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Rok vydání: | 2005 |
Předmět: |
Pharmacology
chemistry.chemical_classification Peptide nucleic acid Oligonucleotide Clinical Biochemistry Antineoplastic Agents Peptide DNA Biology chemistry.chemical_compound chemistry Biochemistry Neoplasms Drug Discovery Nucleic acid Humans Molecular Medicine Protein–DNA interaction Binding site Transcription factor Protein Binding Transcription Factors |
Zdroj: | Expert Opinion on Therapeutic Targets. 9:471-489 |
ISSN: | 1744-7631 1472-8222 |
DOI: | 10.1517/14728222.9.3.471 |
Popis: | DNA-interacting anticancer drugs are able to affect the propensity of DNA to interact with proteins through either reversible binding or covalent bond formation. The effect of the drugs on transcription factor interactions with DNA is reviewed. These effects can be classified as (i) competition between a drug and regulatory protein for target sequences; (ii) weakening of this interaction; (iii) enhancement of this interaction by chemical modification of the DNA and the creation of non-natural binding sites; and (iv) a 'suicide' mechanism, which is observed when a transcription factor induces changes in DNA structure, allowing a drug to bind to a target sequence. Several new strategies -- the antigene approach with oligonucleotides, peptide nucleic acids or locked nucleic acids, and sequence-specific polyamides -- are also reviewed. |
Databáze: | OpenAIRE |
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