Effects of anticancer drugs on transcription factor–DNA interactions

Autor: Marek Gniazdowski, Stephanie M. Nelson, Malgorzata Czyz, William A. Denny
Rok vydání: 2005
Předmět:
Zdroj: Expert Opinion on Therapeutic Targets. 9:471-489
ISSN: 1744-7631
1472-8222
DOI: 10.1517/14728222.9.3.471
Popis: DNA-interacting anticancer drugs are able to affect the propensity of DNA to interact with proteins through either reversible binding or covalent bond formation. The effect of the drugs on transcription factor interactions with DNA is reviewed. These effects can be classified as (i) competition between a drug and regulatory protein for target sequences; (ii) weakening of this interaction; (iii) enhancement of this interaction by chemical modification of the DNA and the creation of non-natural binding sites; and (iv) a 'suicide' mechanism, which is observed when a transcription factor induces changes in DNA structure, allowing a drug to bind to a target sequence. Several new strategies -- the antigene approach with oligonucleotides, peptide nucleic acids or locked nucleic acids, and sequence-specific polyamides -- are also reviewed.
Databáze: OpenAIRE