Mechanisms of cell death in neurodegenerative and retinal diseases: common pathway?
| Autor: | Cecile Lebon, Imene Jaadane, Alicia Torriglia |
|---|---|
| Přispěvatelé: | Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), École nationale vétérinaire d'Alfort (ENVA), HAL-UPMC, Gestionnaire, École nationale vétérinaire - Alfort (ENVA), Centre de Recherche des Cordeliers ( CRC ), Université Paris Diderot - Paris 7 ( UPD7 ) -École pratique des hautes études ( EPHE ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), École nationale vétérinaire d'Alfort ( ENVA ), Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Retinal degeneration Programmed cell death alternative cell death caspase Retina 03 medical and health sciences chemistry.chemical_compound terminal deoxynucleotidyltransferase dUTP nick end labeling Caspase activation medicine Animals Humans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Caspase biology Cell Death Retinal Degeneration apoptosis Retinal Neurodegenerative Diseases medicine.disease Cell biology 030104 developmental biology medicine.anatomical_structure Neurology chemistry Apoptosis [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Caspases biology.protein [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Neurology (clinical) Signal transduction Neuroscience Signal Transduction |
| Zdroj: | Current Opinion in Neurology Current Opinion in Neurology, Lippincott, Williams & Wilkins, 2016, 29 (1), pp.55-60. ⟨10.1097/WCO.0000000000000272⟩ Current Opinion in Neurology, 2016, 29 (1), pp.55-60. ⟨10.1097/WCO.0000000000000272⟩ Current Opinion in Neurology, Lippincott, Williams & Wilkins, 2016, 29 (1), pp.55-60. 〈10.1097/WCO.0000000000000272〉 |
| ISSN: | 1350-7540 |
| DOI: | 10.1097/WCO.0000000000000272⟩ |
| Popis: | International audience; The review intends to draw the attention of researchers working in retinal degenerations on the fact that classical apoptosis, for example, apoptosis triggering caspase activation, may not be the main pathway of cellular demise in this tissue.Former work already showed the difficulty of proving the activation of apoptosis effectors in different models of retinal degeneration. However, these results were not really considered because of the lack of an alternative explanation for cell death. Nowadays, the description of many pathways of cellular demise is filling the gap and other forms of cell death are now described in the retina.The knowledge on the molecular mechanisms of cell death is very important for the development of new therapeutic strategies, as well as for the evaluation of cell death onset in retinal degeneration. |
| Databáze: | OpenAIRE |
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