Chronic carbon disulfide exposure and impaired glucose tolerance
| Autor: | E. Frantík, I. Sperlingová, V. Kujalová |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Xanthurenates medicine.medical_treatment Kynurenic Acid Biochemistry Impaired glucose tolerance Excretion chemistry.chemical_compound Internal medicine medicine Animals Insulin Xanthurenic acid General Environmental Science Glucose tolerance test medicine.diagnostic_test Tryptophan Biological activity Metabolism Glucose Tolerance Test medicine.disease Macaca mulatta Endocrinology chemistry Carbon Disulfide Pyridoxic Acid |
| Zdroj: | Environmental research. 29(1) |
| ISSN: | 0013-9351 |
| Popis: | In monkeys (Macacus rhesus) chronically exposed to a concentration of 1.2 mg CS2/liter air for a period of 20 weeks reduced excretion of 4-pyridoxic acid and enhanced elimination of xanthurenic acid (XA) in urine, due to decreased pyridoxine metabolism, were demonstrated. Impaired glucose tolerance was also determined by means of iv glucose tolerance test (GTT). It was proved that XA, the amount of which is increased due to the changed metabolism of tryptophan, binds to serum insulin with the formation of a XA — insulin complex. The biological activity of this complex is lower than of insulin alone. After degradation of the complex isolated from the serum of chronically exposed monkeys, the presence of XA was demonstrated by spectrofluorometry: one XA molecule binds to one insulin monomer. |
| Databáze: | OpenAIRE |
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