Relations of serum phosphorus levels to echocardiographic left ventricular mass and incidence of heart failure in the community
| Autor: | Philimon Gona, Jayashri Aragam, Emelia J. Benjamin, Ramachandran S. Vasan, Ralph B. D'Agostino, Ravi Dhingra, Thomas J. Wang, William B. Kannel |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Systole Epidemiology Heart Ventricles Renal function Risk Assessment Residence Characteristics Risk Factors Internal medicine Confidence Intervals medicine Humans Computer Simulation Prospective Studies Myocardial infarction Proportional Hazards Models Heart Failure Proteinuria business.industry Proportional hazards model Incidence Phosphorus medicine.disease United States Cross-Sectional Studies Logistic Models Quartile Echocardiography Heart failure Multivariate Analysis Disease Progression Cardiology Female Hypertrophy Left Ventricular medicine.symptom Cardiology and Cardiovascular Medicine business Glomerular Filtration Rate Kidney disease |
| Zdroj: | European Journal of Heart Failure. 12:812-818 |
| ISSN: | 1879-0844 1388-9842 |
| DOI: | 10.1093/eurjhf/hfq106 |
| Popis: | To evaluate the association of serum phosphorus with cardiac structure/function and incident heart failure. Methods We related serum phosphorus to echocardiographic left ventricular (LV) measurements cross-sectionally, and to inci- dent heart failure prospectively in 3300 participants (mean age 44 years, 51% women) free of heart failure, myocardial infarction, and chronic kidney disease (estimated glomerular filtration rate (eGFR),60 mL/min/1.73 m 2 ). Cross- sectionally, serum phosphorus was related positively to LV mass, internal dimensions, and systolic dysfunction. On follow-up (mean 17.4 years), 157 individuals developed heart failure. In models adjusting for established risk factors as time-varying covariates, each mg/dL increment in serum phosphorus was associated with a 1.74-fold risk of heart failure (95% confidence intervals (CI) 1.17-2.59). Individuals in the highest serum phosphorus quartile experienced a two-fold (95% CI 1.28-3.40) risk of heart failure compared with participants in the lowest quartile. These relations were maintained upon additional adjustment for LV mass/dimensions and systolic dysfunction. In ana- lyses restricted to individuals with eGFR .90 mL/min/1.73 m 2 , no proteinuria and serum phosphorus ,4.5 mg/dL, the association of serum phosphorus with heart failure remained robust. Conclusion In our community-based sample, higher serum phosphorus was associated with greater LV mass cross-sectionally, and with an increased risk of heart failure prospectively. |
| Databáze: | OpenAIRE |
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