Genome-wide association studies identified variants for taurine concentration in Japanese Black beef
| Autor: | Nanae Sasago, Shinji Sasaki, Takatoshi Kojima, Hironori Sakuma, Tsuyoshi Ohtake, Tsuyoshi Abe, Masayuki Takeda, Yoshinobu Uemoto |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Taurine Meat Population Single-nucleotide polymorphism Genome-wide association study Beef cattle Biology Polymorphism Single Nucleotide 03 medical and health sciences chemistry.chemical_compound Gene Frequency Animals Allele Amino Acids education Allele frequency Genetic association Oligonucleotide Array Sequence Analysis Genetics education.field_of_study Membrane Glycoproteins 0402 animal and dairy science Membrane Transport Proteins 04 agricultural and veterinary sciences General Medicine 040201 dairy & animal science 030104 developmental biology chemistry beta-Alanine Cattle General Agricultural and Biological Sciences Peptides Genome-Wide Association Study |
| Zdroj: | Animal science journal = Nihon chikusan Gakkaiho. 89(8) |
| ISSN: | 1740-0929 |
| Popis: | We performed genome-wide association studies (GWAS) using the BovineSNP50 array to detect significant single nucleotide polymorphisms (SNPs) that may affect the concentration of 22 free amino acids and three peptides in Japanese Black beef cattle. A total of 574 Japanese Black cattle and 40,657 SNPs from the array were used for this study. Genome-wide significant SNPs were detected for β-alanine (three SNPs on chromosomes 22 and 29) and taurine (26 SNPs on chromosome 22). Importantly, the top two SNPs for taurine were highly significant (p = 6.2 × 10-21 ), and the frequency of the increase-concentration allele (Q) for taurine was found to be 0.73. The Q allele frequency of this population was similar to that of the other unrelated Japanese Black cattle, but different from that of the other breeds. In addition, the significant SNPs were not associated with carcass traits or fatty acid compositions. Interestingly, the top three of the four most significant SNPs for taurine were located near solute carrier family 6, member 6 (SLC6A6), which is a membrane transporter for taurine. We also found two associated variants in the 5'-upstream region of SLC6A6; however, they were less significantly associated than the SNPs from the BovineSNP50 array. |
| Databáze: | OpenAIRE |
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