Monoclonal antibody directed to the PilQ -PilA DSL region in Pseudomonas aeruginosa improves survival of infected mice with antibiotic combination
| Autor: | Maziar Mohammad Akhavan, Mahmood Jeddi-Tehrani, Farzaneh Notash Haghighat, Gholamreza Irajian, Azam Hemmati, Abed Zahedi Bialvaei, Shabnam Razavi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.drug_class 030106 microbiology Antibiotics Ceftazidime Microbial Sensitivity Tests medicine.disease_cause Microbiology Sepsis Mice 03 medical and health sciences Levofloxacin Animals Humans Medicine Pseudomonas Infections biology business.industry Pseudomonas aeruginosa Antibodies Monoclonal medicine.disease Anti-Bacterial Agents Multiple drug resistance 030104 developmental biology Infectious Diseases biology.protein Gentamicin Antibody business medicine.drug |
| Zdroj: | Microbial Pathogenesis. 158:105060 |
| ISSN: | 0882-4010 |
| DOI: | 10.1016/j.micpath.2021.105060 |
| Popis: | The infections caused by Pseudomonas aeruginosa are related to high mortality and morbidity in critically ill patients because of multidrug resistance. Thus, we performed the efficacy of the monoclonal antibody (mAb) against PilQ -PilA DSL region (QA) in combination with antibiotics in a model of P. aeruginosa infection. In the present study, three clinically applicable antibiotics (levofloxacin, ceftazidime and gentamicin) and the anti-QA mAb were utilized for treatment of P. aeruginosa sepsis in mice. Reliably, in comparison with other treatment groups (antibody or antibiotic administration), the combination of antibiotic and anti-QA mAb essentially enhanced the survival of mice infected with P. aeruginosa PAO1. This synergistic effect was due to improved bactericidal effect, which prevented bacterial dissemination to different organs. Consequently, the antibiotic and anti-QA mAb combination gives a new effective strategy for the treatment of P. aeruginosa sepsis, particularly when large numbers of exceptionally virulent strains are present. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect