Retention in event-driven PrEP among young Thai men who have sex with men at risk of HIV acquisition
| Autor: | Jirawat Traikiatphum, Prissana Wongharn, Juthamanee Moonwong, Wipaporn N Songtaweesin, Shawin Vitsupakorn, Athiporn Premgamone, Surinda Kawichai, Thanyawee Puthanakit |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Adolescent Anti-HIV Agents Sexual Behavior Public Health Environmental and Occupational Health HIV Infections Pilot Projects Dermatology Thailand Medication Adherence Sexual and Gender Minorities Young Adult Infectious Diseases Emtricitabine Humans Pharmacology (medical) Pre-Exposure Prophylaxis Homosexuality Male |
| Zdroj: | International journal of STDAIDS. 33(8) |
| ISSN: | 1758-1052 |
| Popis: | Background: Daily pre-exposure prophylaxis (PrEP) regimen of tenofovir/emtricitabine (TDF/FTC) tablet is the standard of care for HIV prevention in Thailand. Event-driven PrEP (ED-PrEP), taking two loading pills 2–24 h prior to sex and two doses afterward, is considered an alternative regimen. This pilot study aimed to describe accuracy of and retention in ED-PrEP use among Thai young men who have sex with men (YMSM).Methods: A cohort of YMSM aged 15–19 years at risk of HIV infection, defined as reporting irregular condom use or having an HIV-positive sexual partner, was enrolled. All participants were provided oral TDF/FTC, condoms, and the “Raincoat” mobile application, which reminds users when to administer ED-PrEP. Participants attended clinic visits at Months 1, 3, and 6 and followed up by phone at Months 2, 4, and 5. Proper use of ED-PrEP was reported in person-months.Results: From August 2020 to July 2021, 36 YMSM with a median age of 18.7 (IQR, 17.5–19.4) years were enrolled. Thirty-two participants (88.9%, 95% CI: 73.9–96.9%) were retained at 6 months. No HIV incidence occurred during this study period. Of 197 person-months of follow-up, 69 (35%) involved sexual activity. In this group, 61% used ED-PrEP correctly. “Unplanned sexual activity” was the most commonly cited reason for incorrect use.Conclusions: YMSM who have infrequent sex had very high retention in ED-PrEP. However, about one-third of the sexually active period, ED-PrEP was not used correctly due to not taking the loading dose, suggesting that this regimen may not be suitable for unanticipated sexual activity. |
| Databáze: | OpenAIRE |
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