Antifungal activity of extracts and phenolic compounds from Deguelia duckeana
| Autor: | Lorena M. Cursino-Hron, Cecilia Veronica Nunez, João Vicente Braga de Souza, Jane V.N. Marinho, André C. de Oliveira, Alita Moura de Lima, Nerilson M. Lima |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Phytochemistry
Lignan Cytotoxicity Flavonoid lcsh:RS1-441 3 4 7 Trimethoxyflavone 5 4 Dihydroxy Isolonchocarpine 01 natural sciences Chalcone Chalcone Derivative General Pharmacology Toxicology and Pharmaceutics Candida albicans Timbó chemistry.chemical_classification biology Traditional medicine 3 5 4 Trimethoxy Stilbene Corpus albicans Amazonian plant 3 5 4 Trimethoxy 4 Prenylstilbene 3 4 7 Trimethoxy Flavonol Phytochemical Flavone Derivative Minimum Inhibitory Concentration Anti-fungal Activity 4 Hydroxylonchocarpine Cryptococcus Neoformans Carbon Nuclear Magnetic Resonance 3 4 Methylenedioxy 7 Methoxyflavone Plant Extract Deguelia Duckeana lcsh:Pharmacy and materia medica Minimum inhibitory concentration Unclassified Drug medicine 4 Hydroxyderricidine Cryptococcus gattii Cryptococcus neoformans Liquid Chromatography-mass Spectrometry Derricidine 010405 organic chemistry 010401 analytical chemistry biology.organism_classification medicine.disease Nonhuman 0104 chemical sciences Cryptococcus Gattii chemistry Stilbene Cryptococcosis Deguelia Duckeana Extract Proton Nuclear Magnetic Resonance Plant Medicinal Product Yangambin 4 Hydroxyderricine |
| Zdroj: | Repositório Institucional do INPA Instituto Nacional de Pesquisas da Amazônia (INPA) instacron:INPA Revista Brasileira de Farmacognosia v.28 n.6 2018 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Vol 28, Iss 6, Pp 697-702 Revista Brasileira de Farmacognosia, Vol 28, Iss 6, Pp 697-702 (2018) |
| Popis: | Candida spp. is associated with almost 80% of all nosocomial fungal infections and is considered a major cause of blood stream infections. In humans, Cryptococcosis is a disease of the lungs caused by the fungi Cryptococcus gattii and Cryptococcus neoformans. It can be potentially fatal, especially in immune-compromised patients. In a search for antifungal drugs, Deguelia duckeana extracts were assayed against these two fungi and also against Candida albicans, which causes candidiasis. Hexane branches and CH2Cl2 root extracts as well as the substances 4-hydroxylonchocarpine, 3,5,4′-trimethoxy-4-prenylstilbene and 3′,4′-methylenedioxy-7-methoxyflavone were assayed to determine the minimal inhibitory concentration. Phytochemical study of CH2Cl2 root and hexane branch extracts from D. duckeana A.M.G. Azevedo, Fabaceae, resulted in the isolation and characterization of nine phenolic compounds: 4-hydroxyderricine, 4-hydroxylonchocarpine, 3′,4′,7-trimethoxy-flavonol, 5,4′-dihydroxy-isolonchocarpine, 4-hydroxyderricidine, derricidine, 3,5,4′-trimethoxy-stilbene, 3′,4′,7-trimethoxyflavone and yangambin. The only active extract was a CH2Cl2 root showing minimal inhibitory concentration 800 μg/ml against C. gattii, and the investigation of compounds obtained from this extract showed that 4-hydroxylonchocarpine was active against all three fungi (C. neoformans, C. gattii and C. albicans). These results suggest that D. duckeana extracts have potential therapeutic value for the treatment of pathogenic fungi. Keywords: Amazonian plant, Chalcone, Flavonoid, Lignan, Stilbene, Timbó |
| Databáze: | OpenAIRE |
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