CdO/CdCO3 nanocomposite physical properties and cytotoxicity against selected breast cancer cell lines

Autor:	P. Mfengwana, Mamello Sekhoacha, K. Saleh, Malik Maaza, N. Matinise, B.T. Sone, R. P. Lefojane, Paballo Direko, Samson Sitheni Mashele
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	0301 basic medicine Multidisciplinary Chemistry Scanning electron microscope Science Nanoparticle 02 engineering and technology 021001 nanoscience & nanotechnology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Ultraviolet visible spectroscopy Transmission electron microscopy Microscopy Cadmium oxide Cadmium nitrate Medicine Fourier transform infrared spectroscopy 0210 nano-technology Nuclear chemistry
Zdroj:	Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
ISSN:	2045-2322
Popis:	Cadmium Oxide nanoparticles have the lowest toxicity when compared to nanoparticles of other semiconductors and they are not detrimental to human and mammalian cells, thereby making them candidates for targeting cancer cells. Synadenium cupulare plant extracts were used to synthesize CdO/CdCO3 nanocomposite using cadmium nitrate tetrahydrate 98% as a precursor salt. The resultant nanoparticles were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy, ultraviolet visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR). The nanoparticles were then screened for effect on breast cancer cell lines (MCF-7 and MDA MB-231) and Vero cell line to determine their growth inhibition effect. Cytotoxicity effect was evaluated using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. XRD showed the peaks of monteponite CdO and otavite CdCO3 nanoparticles. TEM results showed irregular and spherical particles of varying sizes, whilst SEM revealed a non-uniform morphology. FTIR results showed peaks of functional groups which are present in some of the phytochemical compounds found in S. cupulare, and point to the presence of CdO. Annealed CdO/CdCO3 NPs showed selectivity for MCF7 and MDA MB231 in comparison to Vero cell line, thereby supporting the hypothesis that cadmium oxide nanoparticles inhibit growth of cancerous cells more than non-cancerous cells.
Databáze:	OpenAIRE
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