Albumin and apolipoprotein H mRNAs in human plasma as potential clinical biomarkers of liver injury: analyses of plasma liver-specific mRNAs in patients with liver injury
| Autor: | Shingo Okubo, Kenji Takami, Kiyoshi Ashida, Makoto Miyamoto, Dai Ito |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Pathology Health Toxicology and Mutagenesis Clinical Biochemistry Biology Real-Time Polymerase Chain Reaction Biochemistry Elevated serum 03 medical and health sciences Internal medicine medicine Humans In patient RNA Messenger Transcatheter arterial chemoembolization Serum Albumin Aged Liver injury Aged 80 and over Albumin Plasma levels Middle Aged medicine.disease 030104 developmental biology Endocrinology Liver Human plasma Wounds and Injuries Female Apolipoprotein H Biomarkers |
| Zdroj: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 21(4) |
| ISSN: | 1366-5804 |
| Popis: | Context: Plasma liver-specific mRNAs are useful biomarkers of hepatotoxicity in rats.Objective: To investigate the potential application of liver-specific mRNAs as biomarkers for liver injury in humans.Methods: We determined the plasma levels of liver-specific mRNAs by real-time qRT-PCR in healthy donors and patients with liver injury.Results: Plasma levels of albumin (ALB) and apolipoprotein H (APOH) mRNAs increased in patients with elevated serum alanine aminotransferase. These mRNAs also increased in plasma after transcatheter arterial chemoembolization, which induces specific injury to liver.Conclusions: We demonstrated the potential application of plasma ALB and APOH mRNAs as clinical biomarkers for liver injury. |
| Databáze: | OpenAIRE |
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