Measuring Residual Renal Function in Hemodialysis Patients without Urine Collection
| Autor: | Enric Vilar, Ken Farrington, Raja Mohammed Kaja Kamal, Jonathan Wong |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment 030232 urology & nephrology Renal function 030204 cardiovascular system & hematology Kidney Function Tests Sensitivity and Specificity Urine collection device 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Renal Dialysis Humans Medicine Cystatin C Intensive care medicine Urine Specimen Collection Creatinine biology business.industry Beta-2 microglobulin chemistry Nephrology biology.protein Kidney Failure Chronic Female Hemodialysis business Biomarkers Glomerular Filtration Rate Urine collection |
| Zdroj: | Seminars in Dialysis. 30:39-49 |
| ISSN: | 0894-0959 |
| DOI: | 10.1111/sdi.12557 |
| Popis: | Many patients on hemodialysis retain significant residual renal function (RRF) but currently measurement of RRF in routine clinical practice can only be achieved using inter-dialytic urine collections to measure urea and creatinine clearances. Urine collections are difficult and inconvenient for patients and staff, and therefore RRF is not universally measured. Methods to assess RRF without reliance on urine collections are needed since RRF provides useful clinical and prognostic information and also permits the application of incremental hemodialysis techniques. Significant efforts have been made to explore the use of serum based biomarkers such as cystatin C, β-trace protein and β2 -microglobulin to estimate RRF. This article reviews blood-based biomarkers and novel methods using exogenous filtration markers which show potential in estimating RRF in hemodialysis patients without the need for urine collection. |
| Databáze: | OpenAIRE |
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