Novel Subtypes of Pulmonary Emphysema Based on Spatially-Informed Lung Texture Learning: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study
Autor: | Benjamin M. Smith, R. Graham Barr, Elsa D. Angelini, Andrew F. Laine, Jie Yang, Pallavi Balte, John H.M. Austin, Eric A. Hoffman |
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Přispěvatelé: | National Institutes of Health |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
lung texture Pulmonary emphysema Pulmonary disease Computed tomography unsupervised learning Texture (geology) 09 Engineering Mesa Article Pulmonary Disease Chronic Obstructive Lung CT medicine Humans Electrical and Electronic Engineering Lung computer.programming_language Emphysema COPD Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Spatial mapping respiratory system medicine.disease Atherosclerosis Computer Science Applications respiratory tract diseases Nuclear Medicine & Medical Imaging medicine.anatomical_structure Pulmonary Emphysema spatial mapping 08 Information and Computing Sciences Radiology business computer Software |
Zdroj: | IEEE transactions on medical imaging |
ISSN: | 1558-254X |
Popis: | Pulmonary emphysema overlaps considerably with chronic obstructive pulmonary disease (COPD), and is traditionally subcategorized into three subtypes previously identified on autopsy. Unsupervised learning of emphysema subtypes on computed tomography (CT) opens the way to new definitions of emphysema subtypes and eliminates the need of thorough manual labeling. However, CT-based emphysema subtypes have been limited to texture-based patterns without considering spatial location. In this work, we introduce a standardized spatial mapping of the lung for quantitative study of lung texture location and propose a novel framework for combining spatial and texture information to discover spatially-informed lung texture patterns (sLTPs) that represent novel emphysema subtype candidates. Exploiting two cohorts of full-lung CT scans from the MESA COPD (n = 317) and EMCAP (n = 22) studies, we first show that our spatial mapping enables population-wide study of emphysema spatial location. We then evaluate the characteristics of the sLTPs discovered on MESA COPD, and show that they are reproducible, able to encode standard emphysema subtypes, and associated with physiological symptoms. |
Databáze: | OpenAIRE |
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