A Cascade Phosphinoylation/Cyclization/Desulfonylation Process for the Synthesis of 3-Phosphinoylindoles
| Autor: | Yufen Zhao, Liangliang Zhang, Pengbo Zhang, Yuzhen Gao, Guozhang Lu, Guo Tang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Indole test
Indoles Silver Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry Oxides 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Combinatorial chemistry Catalysis Cycloaddition 0104 chemical sciences Organophosphorus Compounds Cyclization Cascade Organic chemistry Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 18:1242-1245 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.6b00056 |
| Popis: | 3-Phosphinoylindole derivatives play important roles as pharmaceutical drugs and ligands. A new method for the synthesis of 3-phosphinoylindole derivatives has been achieved through silver-mediated cycloaddition between N-Ts-2-alkynylaniline derivatives and H-phosphine oxides. This transformation offers a straightforward route to the formation of the C-P bond, indole ring, and desulfonylation in one step. |
| Databáze: | OpenAIRE |
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