TRPC channels in exercise-mimetic therapy
Autor: | Sayaka Oda, Tomohiro Tanaka, Akiyuki Nishimura, Motohiro Nishida, Takuro Numaga-Tomita, Kazuhiro Nishiyama |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Redox signaling Plasticity Physiology Clinical Biochemistry Physical exercise Pharmacology TRPC6 03 medical and health sciences Transient receptor potential channel 0302 clinical medicine TRPC3 Protein-protein interaction Transient Receptor Potential Channels Physiology (medical) Physical Conditioning Animal Myocyte Animals Humans Receptor Exercise TRPC NADPH oxidase Invited Review biology Chemistry Myocardium NADPH Oxidases Remodeling Exercise Therapy 030104 developmental biology Transient receptor potential Type C Phospholipases biology.protein Reactive Oxygen Species 030217 neurology & neurosurgery |
Zdroj: | Pflugers Archiv |
ISSN: | 1432-2013 0031-6768 |
Popis: | Physical exercise yields beneficial effects on all types of muscle cells, which are essential for the maintenance of cardiovascular homeostasis and good blood circulation. Daily moderate exercise increases systemic antioxidative capacity, which can lead to the prevention of the onset and progression of oxidative stress-related diseases. Therefore, exercise is now widely accepted as one of the best therapeutic strategies for the treatment of ischemic (hypoxic) diseases. Canonical transient receptor potential (TRPC) proteins are non-selective cation channels activated by mechanical stress and/or stimulation of phospholipase C-coupled surface receptors. TRPC channels, especially diacylglycerol-activated TRPC channels (TRPC3 and TRPC6; TRPC3/6), play a key role in the development of cardiovascular remodeling. We have recently found that physical interaction between TRPC3 and NADPH oxidase (Nox) 2 under hypoxic stress promotes Nox2-dependent reactive oxygen species (ROS) production and mediates rodent cardiac plasticity, and inhibition of the TRPC3-Nox2 protein complex results in enhancement of myocardial compliance and flexibility similar to that observed in exercise-treated hearts. In this review, we describe current understanding of the roles of TRPC channels in striated muscle (patho)physiology and propose that targeting TRPC-based protein complexes could be a new strategy to imitate exercise therapy. |
Databáze: | OpenAIRE |
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