Epicardial adipocyte size does not correlate with body mass index
| Autor: | Regis R. Lamberts, Sean Coffey, Rexson Tse, Aram A. Babakr, Peter P. Jones, Hamish M. Aitken-Buck |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Abdominal Fat Subcutaneous Fat Adipose tissue 030204 cardiovascular system & hematology Body Mass Index Pathology and Forensic Medicine Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Adipocyte Adipocytes Humans Medicine Obesity Prospective Studies Adiposity Aged Cell Size business.industry Histology General Medicine Middle Aged medicine.disease 030104 developmental biology Endocrinology chemistry Epicardial adipose tissue Female Autopsy Cardiology and Cardiovascular Medicine business Pericardium Body mass index |
| Zdroj: | Cardiovascular Pathology. 43:107144 |
| ISSN: | 1054-8807 |
| DOI: | 10.1016/j.carpath.2019.07.003 |
| Popis: | Epicardial adipose tissue (EAT) deposition has a strong association with aspects of metabolic dysfunction, including obesity. The size of the EAT adipocytes in relation to obesity, however, has rarely been researched. Therefore, to contextualise EAT within the broader framework of pathophysiological adipocyte size changes in obesity, we aimed to determine whether EAT adipocyte size is associated with body mass index (BMI).During routine post-mortem examination, adipose tissue biopsies were obtained from four depots of 43 cases, including EAT, as well as pericardial (PAT), appendix mesenteric (AAT), and clavicular subcutaneous (SAT) adipose tissues. Tissues were fixed, sectioned, and stained using haematoxylin and eosin. The size (measured as area) of each adipocyte imaged from the depots was analysed in relation to BMI.Mean size of EAT adipocytes was significantly smaller than that from SAT and AAT depots, while not differing from PAT adipocytes. BMI positively correlated with the size of adipocytes isolated from SAT (r=0.5893, P.0001), PAT (r=0.5854, P.0001), and AAT (r=0.5829, P.0001) depots, but not from EAT (r=0.1242, P=.4274), even after multivariate adjustment for age and sex.EAT adipocyte size is not associated with increased BMI despite significant associations within adipocytes from other adipose depots. |
| Databáze: | OpenAIRE |
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