Investigation of tick-borne viruses as pathogens of humans in South Africa and evidence of Dugbe virus infection in a patient with prolonged thrombocytopenia
| Autor: | B. Patterson, Patricia A. Leman, Robert Swanepoel, F. J. Burt, D. C. Spencer |
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| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Male
Nairobi Sheep Disease Epidemiology Enzyme-Linked Immunosorbent Assay Biology Tick Cross Reactions Antibodies Viral South Africa Seroepidemiologic Studies medicine Animals Humans Bites and Stings Tick-borne disease Nairovirus Sheep Middle Aged medicine.disease biology.organism_classification Virology Thrombocytopenia Infectious Diseases Tick-Borne Diseases Cattle Hemorrhagic Fever Crimean Viral disease Bunyaviridae Hyalomma Crimean Congo hemorrhagic fever virus Louping ill Research Article |
| Popis: | SUMMARYIn the course of investigating suspected cases of viral haemorrhagic fever in South Africa patients were encountered who had been bitten by ticks, but who lacked evidence of infection with Crimean–Congo haemorrhagic fever (CCHF) virus or non-viral tick-borne agents. Cattle sera were tested by enzyme-linked immunoassay to determine whether tick-borne viruses other than CCHF occur in the country. The prevalence of antibody in cattle sera was 905/2116 (42·8%) for CCHF virus, 70/1358 (5·2%) for Dugbe, 21/1358 (1·5%) for louping ill, 6/450 (1·3%) for West Nile, 7/1358 (0·5%) for Nairobi sheep disease, 3/625 (0·5%) for Kadam and 2/450 (0·4%) for Chenuda. No reactions were recorded with Hazara, Bahig, Bhanja, Thogoto and Dhori viruses. The CCHF findings confirmed previous observations that the virus is widely prevalent within the distribution range of ticks of the genusHyalomma, while antibody activity to Dugbe antigen was detected only within the distribution range of the tickAmblyomma hebraeum. Cross-reactivity for the nairoviruses, Hazara, Nairobi sheep disease and Dugbe, was detected in serum samples from 3/72 human patients with confirmed CCHF infection, and serum from 1/162 other patients reacted monospecifically with Dugbe antigen. The latter patient suffered from febrile illness with prolonged thrombocytopenia. |
| Databáze: | OpenAIRE |
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