Changes in growth, growth hormone, and insulin-like growth factor-I (IGF-I) after orthotopic liver transplantation
| Autor: | Broto J, D Infante, J Lloret, C. Castro de Kolster, V. Martínez, N. Potau, R Tormo |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Orthotopic liver transplantation medicine.medical_treatment Radioimmunoassay Growth Growth hormone Chronic liver disease Insulin-like growth factor Internal medicine medicine Humans Insulin-Like Growth Factor I Child business.industry Liver Diseases Growth factor General Medicine medicine.disease Pathophysiology Liver Transplantation Transplantation Treatment Outcome Endocrinology Liver Child Preschool Growth Hormone Chronic Disease Pediatrics Perinatology and Child Health Female Surgery Liver function business Follow-Up Studies |
| Zdroj: | Pediatric Surgery International. 13:323-326 |
| ISSN: | 1437-9813 0179-0358 |
| DOI: | 10.1007/s003830050330 |
| Popis: | Growth failure is an important consequence of chronic liver disease in childhood. Insulin-like growth factor-I (IGF-I), which is synthesized and released by the liver, plays an important role as a growth regulator in humans. We examined the growth hormone (GH)/IGF-I axis before and after orthotopic liver transplantation (LT) in 14 children aged between 2 and 11 years (mean 5.6 +/- 1.1 years). Pre-transplantation serum GH levels (7.5 +/- 1.2 ng/ml) were significantly higher (P0.001) compared with controls (5 +/- 0.5 ng/ml). However, post-transplantation levels (1.8 +/- 0.8 ng/ml) did not differ from those in the control group. Serum IGF-I levels showed a statistically significant increase after LT (20.1 +/- 9.4 vs 190 +/- 66.2 ng/ml; P0.001) and became indistinguishable from the levels in the control group (180 +/- 96 ng/ml). In comparison with pre-transplantation data (z - 2.70), there was an increase in height 4 years postoperatively (z - 1.68). Catch-up growth was highly significant, in particular during the 1st year after LT (z -1. 58 +/- 1.63 vs 2.59 +/- 5.29; P0.01). We conclude that a GH resistance state found in patients with severe chronic liver disease reverted following LT. Given that IGF-1 depends upon liver function, this could be one of the main factors in the significant catch-up growth in pediatric LT recipients. |
| Databáze: | OpenAIRE |
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