Hepatic injury caused by benzbromarone
| Autor: | Bruno H. Stricker, Melanie M. van der Klauw, Pieternella M. Houtman, Pieter Spoelstra |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Toxic hepatitis
medicine.medical_specialty Gastroenterology Benzbromarone chemistry.chemical_compound Internal medicine medicine Humans Methyldopa Aspartate Aminotransferases Aged Hepatitis Endoscopic retrograde cholangiopancreatography Hepatology biology medicine.diagnostic_test business.industry Goiter Liver Diseases Hepatitis A Alanine Transaminase medicine.disease Discontinuation Surgery chemistry Alanine transaminase Liver biology.protein Female medicine.symptom Chemical and Drug Induced Liver Injury business medicine.drug |
| Zdroj: | Journal of hepatology. 20(3) |
| ISSN: | 0168-8278 |
| Popis: | This case study describes a woman who developed a predominantly hepatocellular injury, approximately 3 months after starting treatment with 100 mg benzbromarone daily. She had also taken 250 mg methyldopa daily for several years. Infections with hepatitis A and B were excluded serologically, no autoantibodies were demonstrated, and ultrasonography and endoscopic retrograde cholangiopancreatography did not show extrahepatic obstruction. The patient recovered after discontinuation of both drugs. Two years later, readministration of benzbromarone was followed by a relapse. Later, methyldopa was used without problems. We conclude that hepatic injury in this patient was caused by benzbromarone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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