Abnormal neuroendocrine response to clomipramine in hereditary affective psychosis
| Autor: | Wolfgang Gaebel, Georg Auburger, Marcella Rietschel, Hans-Wilhelm Müller, Uwe Henning, Christian Werner, Ansgar Klimke, Guillermo Orozco, Johanna Thünker, Marco Tosch, Fermín Mayoral, Fabio Rivas, Rolf Larisch, Joachim Cordes |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Clomipramine Bipolar Disorder Genotype Hydrocortisone Personality Inventory Poison control Antidepressive Agents Tricyclic Serotonergic Young Adult Reference Values Internal medicine medicine Humans Genetic Predisposition to Disease Bipolar disorder Major depressive episode Infusions Intravenous Depression (differential diagnoses) Aged Serotonin Plasma Membrane Transport Proteins Depressive Disorder Major Middle Aged medicine.disease Prolactin Psychiatry and Mental health Clinical Psychology Suicide Endocrinology Anxiety Female medicine.symptom Psychology hormones hormone substitutes and hormone antagonists Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Depression and anxiety. 26(8) |
| ISSN: | 1520-6394 |
| Popis: | Background: Blunting of prolactin response after serotonergic stimulation during a major depressive episode has been described by several investigators. In this study, the neuroendocrine responses to clomipramine were assessed in remitted patients suffering from hereditary depression. Methods: Twenty remitted patients from 11 large families with multigenerational, multiple cases of major affective disorder (bipolar disorder n=15, recurrent depression n=5, according DSM-IV) and 12 healthy relatives were investigated. After intravenous application of 12.5 mg of the serotonin re-uptake inhibitor clomipramine, serum prolactin and cortisol levels were analysed. Results: Patients and comparison group did not differ significantly with respect to age, baseline prolactin and cortisol concentrations. A gender effect was found in an exploratory analysis for prolactin but not for cortisol and therefore the data for prolactin were analysed seperately. After clomipramine infusion, the increase of cortisol was significantly lower in patients than in the comparison group (P=.046). For prolactin, this effect could be found in the male (P=.012) as well as in the female (P=.007) subsample. Conclusions: These results suggest that blunted prolactin and cortisol responses to serotonergic stimulation are characteristic for remitted depressive patients with previous episodes of major affective disorders. Depression and Anxiety, 2009. © 2009 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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