Medical Management of Constipation in Elderly Patients: Systematic Review
| Autor: | Seong Eun Kim, Yoo Jin Lee, Seon-Young Park, Seung Joo Kang, Young Sin Cho, Jeong Eun Shin, Jung-Wook Kim, Tae Hee Lee, Han Seung Ryu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Constipation Lactitol Prucalopride business.industry medicine.medical_treatment Gastroenterology Laxative Calcium Polycarbophil Lubiprostone Lactulose chemistry.chemical_compound Elobixibat chemistry Laxatives Internal medicine medicine Systematic Review Neurology (clinical) medicine.symptom business Aged medicine.drug |
| Zdroj: | Journal of Neurogastroenterology and Motility |
| ISSN: | 2093-0887 2093-0879 |
| Popis: | Background/aims Constipation is a common gastrointestinal problem in the elderly. Because of the limitations of life style modifications and the comorbidity, laxative use is also very common. Therefore, this study reviews the latest literature on the effect and safety of laxative in the elderly. Methods A systematic review of randomized controlled trials investigating the effectiveness and safety of laxatives for constipation in elderly patients over 65 years old were performed using the following databases: PubMed, EMBASE, and the Cochrane Library. Results Twenty-three randomized controlled trials were included in this review. Among the selected studies, 9 studies compared laxative with placebo and 5 studies compared laxatives of the same type. Four studies compared different types of laxatives or compared combination agents. Five studies compared novel medications such as prucalopride, lubiprostone, and elobixibat with placebo. Psyllium, calcium polycarbophil, lactulose syrup, lactitol, polyethylene glycol, magnesium hydroxide, stimulant laxative with or without fiber, and other medications were more effective than placebo in elderly constipation patients in short-term. Generally, the frequency and severity of adverse effects of laxative were similar between the arms of studies. Conclusions Bulk laxative, osmotic laxative, stimulant laxative with or without fiber, and other medications can be used in elderly patients in short-term within 3 months with reasonable safety. However, the quality of included studies was not high and most of studies was conducted in a small number of patients. Among these laxatives, polyethylene glycol seems to be safe and effective in long-term use of about 6 months in elderly patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|