Relationship of intrahepatic bile duct hyperplasia to cholangiocellular carcinoma
| Autor: | Masafumi Ito, Masanori Kurashina, Norio Hirabayasi, Sadao Kozuka, Nobuo Nakasima |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Pathology Intrahepatic bile ducts Gastroenterology Atypical hyperplasia Adenoma Bile Duct Sex Factors Japan Internal medicine Carcinoma medicine Humans In patient Aged Aged 80 and over Hyperplasia business.industry Carcinoma in situ Age Factors Middle Aged medicine.disease medicine.anatomical_structure Bile Ducts Intrahepatic Oncology Cholangiocellular carcinoma Bile Duct Neoplasms business Duct (anatomy) Precancerous Conditions Carcinoma in Situ |
| Zdroj: | Cancer. 61(12) |
| ISSN: | 0008-543X |
| Popis: | To investigate the relationship between intrahepatic bile duct hyperplasia and cholangiocellular carcinoma, 27 patients with cholangiocellular carcinoma (including biliary cystadenocarcinoma) and 303 controls were histologically examined. Livers with cholangiocellular carcinoma were closely associated with hyperplasia (100%), atypical hyperplasia (77.8%), and carcinoma in situ (51.9%). Transition from hyperplasia to atypical hyperplasia, and from atypical hyperplasia to carcinoma, was often observed. In the controls, hyperplasia was frequent in those older than 30 years of age, whereas carcinoma was frequent in patients from 50 to 80 years of age. Of the intrahepatic bile ducts examined, the large duct showed the highest incidence of hyperplasia, atypical hyperplasia, and carcinoma in situ. All 27 cases of cholangiocellular carcinoma originated in, or near, the hilus of the liver. These findings suggest that cholangiocellular carcinoma frequently develops from bile duct hyperplasia. |
| Databáze: | OpenAIRE |
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