Circulation of genotype 4 hepatitis E virus in Europe: First autochthonous hepatitis E infection in France
| Autor: | Sophie Tesse, Marie-Josée Wendling, Luc Fornecker, Christine Bigaillon, Bruno Lioure, Elisabeth Nicand, Françoise Stoll-Keller |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Genotype Acute myeloblastic leukemia viruses Molecular Sequence Data Population Viremia Biology medicine.disease_cause Immunocompromised Host Hepatitis E virus Virology medicine Animals Cluster Analysis Humans education Phylogeny education.field_of_study Transmission (medicine) virus diseases Sequence Analysis DNA medicine.disease Hepatitis E digestive system diseases Leukemia Infectious Diseases Immunology Female France |
| Zdroj: | Journal of Clinical Virology. 54:197-200 |
| ISSN: | 1386-6532 |
| Popis: | Background Human HEV infections reported in Europe without previous travel to endemic regions are linked to exposure to genotype 3 Hepatitis E virus (HEV).Genotype 3 is widely distributed through human cases and zoonotic reservoir. The geographical distribution of genotype 4 is limited to Asian countries. Objectives The first human case of autochthonous genotype 4 hepatitis E infectionwasreported in France. Study design The HEV infection was described in an immunosuppressed patient, presenting an acute myeloblastic leukemia. Investigation of the case was performed on detection of HEV markers in the patient and in the environment. Results Hepatitis E infection was diagnosed on the basis of HEV RNA viremia, and detection of anti-HEV IgM. The prognostic of leukemia was favorable and HEV was cleared without relapsing. HEV isolate was classified into genotype 4. Conclusions The recent characterization of genotype 4 HEV through swine surveillance in Europe and the description of the first human case in France open interesting questions about the circulation of this genotype: health risks in human population, transmission patterns, and zoonotic reservoir. |
| Databáze: | OpenAIRE |
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