Short-Term (-)-Hydroxycitrate Ingestion Increases Fat Oxidation during Exercise in Athletes
| Autor: | Itaru Watanabe, Tae-Dong Kwon, Woong-Ki Lee, Yasuyuki Ohishi, Heajung Suh, Sungpil Ryu, Hironori Tomi, Kiwon Lim |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Lipolysis Medicine (miscellaneous) Physical exercise Fatty Acids Nonesterified Carbohydrate metabolism Placebo chemistry.chemical_compound Oxygen Consumption Endurance training Internal medicine medicine Humans Ingestion Citrates Exercise physiology Exercise Respiratory exchange ratio Nutrition and Dietetics Glycogen business.industry Respiration Bicycling Endocrinology Adipose Tissue chemistry Exercise Test Physical Endurance Physical therapy Blood Gas Analysis business Oxidation-Reduction |
| Zdroj: | Journal of Nutritional Science and Vitaminology. 48:128-133 |
| ISSN: | 1881-7742 0301-4800 |
| DOI: | 10.3177/jnsv.48.128 |
| Popis: | (-)-Hydroxycitrate (HCA) is known to inhibit increasing malonyl CoA concentration during endurance exercise. Furthermore, a short-term administration of HCA enhances endurance exercise performance in mice. Therefore we investigated the short-term administration of HCA on the exercise performance of athletes. Subjects were administered 250 mg of HCA or placebo as a control (CON) for 5 d, after each time performing cycle ergometer exercise at 60% VO2max for 60 min followed by 80% VO2max until exhaustion. Blood was collected and expired gas samples analyzed at rest and every 15 min. The respiratory exchange ratio was significantly lower in the HCA trial than in the CON trial (p < 0.05). Fat oxidation was significantly increased by short-term administration of HCA, and carbohydrate oxidation was significantly decreased (p < 0.05) during exercise, presumably resulting in increasing the cycle ergometer exercise time to exhaustion after 1 h of 60% VO2max exercise (p < 0.05). These results suggest that a short-term administration of HCA enhances endurance performance with increasing fat oxidation, which spares glycogen utilization during moderate intensity exercise in athletes. |
| Databáze: | OpenAIRE |
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