Clinical and microbiological characteristics of Eggerthella lenta bacteremia at a Japanese tertiary hospital
| Autor: | Norifumi Shigemoto, Michiya Yokozaki, Hiroki Kitagawa, Yumiko Koba, Toshihito Nomura, Kayoko Tadera, Seiya Kashiyama, Keitaro Omori, Hiroki Ohge, Toshinori Hara, Rie Nagaoka |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty 030106 microbiology Perforation (oil well) Bacteremia Eggerthella lenta Microbial Sensitivity Tests Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Japan Internal medicine medicine Humans Pharmacology (medical) Blood culture 030212 general & internal medicine Retrospective Studies medicine.diagnostic_test business.industry bacterial infections and mycoses Antimicrobial medicine.disease Anti-Bacterial Agents Actinobacteria Metronidazole Infectious Diseases Piperacillin/tazobactam business medicine.drug |
| Zdroj: | Journal of Infection and Chemotherapy. 27:1261-1264 |
| ISSN: | 1341-321X |
| DOI: | 10.1016/j.jiac.2021.03.019 |
| Popis: | Eggerthella lenta is an important cause of anaerobic bloodstream infections and is associated with high mortality. However, there are few reports of E. lenta infection in Japan. This study aimed to evaluate the clinical and microbiological characteristics of bacteremia caused by E. lenta in Hiroshima, Japan. We retrospectively analyzed E. lenta bacteremia patients at the Hiroshima University Hospital between January 2012 and December 2020. During the study period, 14 patients with E. lenta bacteremia were identified. All E. lenta isolates were cultured in anaerobic bottles, and the median time to blood culture positivity was 52.9 h. In most cases (85.6%), the source of E. lenta bacteremia was associated with intra-abdominal infections, and colon perforation was the most frequent source of E. lenta bacteremia (42.9%, n = 6). Antimicrobial susceptibility testing showed high minimal inhibitory concentrations (MIC) of piperacillin-tazobactam (TZP) and 100% susceptibility to ampicillin-sulbactam, carbapenems, and metronidazole. This study demonstrates that E. lenta bacteremia is associated with intra-abdominal infections, particularly colon perforation, and a high MIC of TZP. When gram-positive anaerobes are detected in the blood cultures of patients with severe intra-abdominal infections, clinicians should suspect E. lenta, and it may be better to change antimicrobial agents from TZP. |
| Databáze: | OpenAIRE |
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