Organoid cultures for the analysis of cancer phenotypes
| Autor: | Hans Clevers, Norman Sachs |
|---|---|
| Přispěvatelé: | Hubrecht Institute for Developmental Biology and Stem Cell Research |
| Rok vydání: | 2014 |
| Předmět: |
Tumor
Drug screens Cancer Model Treatment options Cancer Biology Bioinformatics medicine.disease Xenograft Model Antitumor Assays Anticancer drug Phenotype Cell Line Organoids Tissue Culture Techniques Basic research Cell Line Tumor Neoplasms Genetics Cancer research Organoid medicine Animals Humans Developmental Biology |
| Zdroj: | Current Opinion in Genetics & Development, 24, 68-73. Elsevier B.V. |
| ISSN: | 0959-437X |
| Popis: | Preclinical models of cancer are essential for a basic understanding of cancer biology and its translation into efficient treatment options for affected patients. Cancer cell lines and xenografts derived directly from primary human tumors have proven very valuable in fundamental oncology research and anticancer drug discovery. Both models inherently comprise advantages and caveats that have to be accounted for. We will outline in these and discuss primary patient derived organoids as third preclinical cancer model. We propose that cancer organoids could potentially fill the gap between simple cancer cell lines suitable for high-throughput screens and complicated, but physiologically relevant xenografts. The resulting applications for cancer organoids range from basic research to drug screens and patient stratification. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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