Impact of intramural leiomyomata in patients with a normal endometrial cavity on in vitro fertilization–embryo transfer cycle outcome
| Autor: | Annette K. Lietz, Eric S. Surrey, William B. Schoolcraft |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Fertilization in Vitro Controlled ovarian hyperstimulation Reproductive technology Endometrium Chorionic Gonadotropin Pregnancy medicine Humans Embryo Implantation Sperm Injections Intracytoplasmic Retrospective Studies Gynecology In vitro fertilisation Estradiol Leiomyoma medicine.diagnostic_test business.industry Uterus Pregnancy Outcome Obstetrics and Gynecology Embryo Transfer medicine.disease female genital diseases and pregnancy complications Embryo transfer Blastocyst medicine.anatomical_structure Reproductive Medicine Hysteroscopy In utero Case-Control Studies Pulsatile Flow Uterine Neoplasms Regression Analysis Female Follicle Stimulating Hormone business |
| Zdroj: | Fertility and Sterility. 75:405-410 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(00)01714-3 |
| Popis: | Assess the impact of intramural uterine leiomyomata and a normal endometrial cavity on IVF-ET cycle outcome.Retrospective case-controlled analysis.Tertiary-care-assisted reproductive technology program.Three hundred ninety-nine consecutive fresh IVF-ET cycles were performed in patients with a normal precycle diagnostic hysteroscopy; patients were divided into four groups. Group 1: positive leiomyomata, age40 years (n = 51 cycles); group 2: negative leiomyomata, age40 years (n = 57 cycles); group 3: positive leiomyomata, ageor =40 years (n = 22 cycles); group 4: negative leiomyomata, ageor =40 years (n = 59 cycles). A subgroup of all group 2 patients aged 35-39 (group 2A, n = 113 cycles) was also evaluated as an additional control.Controlled ovarian hyperstimulation, IVF-ET.Implantation (IR), live birth (LBR) rates.There were no significant differences in LBR among age-matched controls: group 1 (49%) versus 2 (57.5%) or 2A (57%) and group 3 (40.9%) versus 4 (32.2%). IR was significantly lower in group 1 (21.4%) versus 2 (33.3%) or 2A (33.9%) but not in group 3 (17.5%) versus 4 (11.6%). Implantation did not correlate with either mean leiomyoma diameter or volume.[1] LBR was not affected by the presence of intramural leiomyoma in IVF-ET patients with hysteroscopically normal endometrial cavities. [2] A significant decrease in IR was only noted in patients40 years old. [3] Given the relatively high LBR in all groups, prophylactic surgical intervention cannot be justified, but precycle hysteroscopy evaluation is recommended. |
| Databáze: | OpenAIRE |
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