Surfactant-Stripped Semiconducting Polymer Micelles for Tumor Theranostics and Deep Tissue Imaging in the NIR-II Window
| Autor: | Yuanmeng Ding, Jibin Song, Chulhong Kim, Yong Fan, Xingyue Yang, Zhen Jiang, Byullee Park, Moongyu Han, Xiaojie Wang, Jiamin Ye, Yumiao Zhang, Gengqi Liu |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Polymers Signal Micelle Light scattering Biomaterials Photoacoustic Techniques Mice Surface-Active Agents Pulmonary surfactant Neoplasms Animals General Materials Science Precision Medicine Absorption (electromagnetic radiation) Micelles chemistry.chemical_classification Near-infrared spectroscopy General Chemistry Polymer Poloxamer Phototherapy Rats chemistry Nanoparticles Biotechnology Biomedical engineering |
| Zdroj: | Small (Weinheim an der Bergstrasse, Germany). 18(6) |
| ISSN: | 1613-6829 |
| Popis: | Photoacoustic imaging (PA) in the second near infrared (NIR-II) window presents key advantages for deep tissue imaging owing to reduced light scattering and low background signal from biological structures. Here, a thiadiazoloquinoxaline-based semiconducting polymer (SP) with strong absorption in the NIR-II region is reported. After encapsulation of SP in Pluronic F127 (F127) followed by removal of excess surfactant, a dual functional polymer system named surfactant-stripped semiconductor polymeric micelles (SSS-micelles) are generated with water solubility, storage stability, and high photothermal conversion efficiency, permitting tumor theranostics in a mouse model. SSS-micelles have a wideband absorption in the NIR-II window, allowing for the PA imaging at both 1064 and 1300 nm wavelengths. The PA signal of the SSS-micelles can be detected through 6.5 cm of chicken breast tissue in vitro. In mice or rats, SSS-micelles can be visualized in bladder and intestine overlaid 5 cm (signal to noise ratio, SNR ≈ 17 dB) and 5.8 cm (SNR over 10 dB) chicken breast tissue, respectively. This work demonstrates the SSS-micelles as a nanoplatform for deep tissue theranostics. |
| Databáze: | OpenAIRE |
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