Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy
Autor: | Stefano Palazzolo, Emmanuele Ambrosi, Mohamad Hadla, Isabella Caligiuri, Giuseppe Toffoli, Alvise Benedetti, Tiziano Tuccinardi, Samer Bayda, Marco Agostini, Enrico Pontoglio, Giuseppe Corona, Vinit Kumar, Flavio Rizzolio, Vincenzo Canzonieri, Pietro Riello |
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Přispěvatelé: | Bayda, Samer, Hadla, Mohamad, Palazzolo, Stefano, Kumar, Vinit, Caligiuri, Isabella, Ambrosi, Emmanuele, Pontoglio, Enrico, Agostini, Marco, Tuccinardi, Tiziano, Benedetti, Alvise, Riello, Pietro, Canzonieri, Vincenzo, Corona, Giuseppe, Toffoli, Giuseppe, Rizzolio, Flavio |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Carbon nanoparticles
Carbon Nanoparticles Pharmaceutical Science Mice Nude Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Carbon Nanoparticle Nanomaterials Drug Delivery Systems Cancer Doxorubicin Drug delivery Cell Line Tumor Neoplasms medicine Distribution (pharmacology) Animals Humans Free drug 3003 Drug Carriers Antibiotics Antineoplastic Chemistry 021001 nanoscience & nanotechnology Settore CHIM/08 - Chimica Farmaceutica Microvesicles Carbon 0104 chemical sciences Targeted drug delivery Nanomedicine Nanoparticles Female 0210 nano-technology medicine.drug |
Popis: | Nanomedicine requires intelligent and non-toxic nanomaterials for real clinical applications. Carbon materials possess interesting properties but with some limitations due to toxic effects. Interest in carbon nanoparticles (CNPs) is increasing because they are considered green materials with tunable optical properties, overcoming the problem of toxicity associated with quantum dots or nanocrystals, and can be utilized as smart drug delivery systems. Using black tea as a raw material, we synthesized CNPs with a narrow size distribution, tunable optical properties covering visible to deep red absorption, non-toxicity and easy synthesis for large-scale production. We utilized these CNPs to label subcellular structures such as exosomes. More importantly, these new CNPs can escape lysosomal sequestration and rapidly distribute themselves in the cytoplasm to release doxorubicin (doxo) with better efficacy than the free drug. The release of doxo from CNPs was optimal at low pH, similar to the tumour microenvironment. These CNPs were non-toxic in mice and reduced the tumour burden when loaded with doxo due to an improved pharmacokinetics profile. In summary, we created a new delivery system that is potentially useful for improving cancer treatments and opening a new window for tagging microvesicles utilized in liquid biopsies. |
Databáze: | OpenAIRE |
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