Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of amyotrophic lateral sclerosis patients
| Autor: | Mikio Shoji, Takeshi Hayashi, Isao Nagano, Hisashi Narai, Koji Abe, Mito Shiote, Tetsuro Murakami, Tetsuya Nagata |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Pathology Programmed cell death VEGF receptors Enzyme-Linked Immunosorbent Assay Disease Gastroenterology Statistics Nonparametric chemistry.chemical_compound Cerebrospinal fluid Internal medicine Humans Spinocerebellar Ataxias Medicine Amyotrophic lateral sclerosis Chemokine CCL2 Aged Aged 80 and over biology business.industry Monocyte Amyotrophic Lateral Sclerosis Parkinson Disease General Medicine Middle Aged medicine.disease Up-Regulation Vascular endothelial growth factor medicine.anatomical_structure Neurology chemistry Spinocerebellar ataxia biology.protein Female Neurology (clinical) business |
| Zdroj: | Neurological Research. 29:772-776 |
| ISSN: | 1743-1328 0161-6412 |
| DOI: | 10.1179/016164107x229795 |
| Popis: | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with progressive cell death of upper and lower motor neurons. In this study, we measured monocyte chemotactic protein-1 (MCP-1) and vascular endothelial growth factor (VEGF) levels in cerebrospinal fluid (CSF) and serum by enzyme-linked immunosorbent assay (ELISA) in 42 ALS patients, and compared these levels with those of control subjects with other neurodegenerative disorders or with those of normal controls. MCP-1 levels in CSF were significantly higher in ALS patients than in the control group. VEGF levels in CSF tended to be lower in ALS patients than in the control group, but not significantly. A positive correlation was found between MCP-1 levels in CSF of ALS patients and the total Norris scale. The elevation of MCP-1/VEGF ratio in CSF was more specific to ALS patients compared to other neurological diseases such as Parkinson's disease (PD) and spinocerebellar ataxia (SCA) and to controls. Our data suggested that both MCP-1 levels and MCP-1/VEGF ratio in CSF may be useful markers for the clinical diagnosis of ALS. |
| Databáze: | OpenAIRE |
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