Formulas for Calculating Calcium Values Underestimate Hypocalcemia in Hemodialysis Patients
| Autor: | Frans A. L. Van Der Horst, Sebastiaan J Huisman, Ference J. Loupatty, Thijs C van Holten |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry 030232 urology & nephrology Urology Parathyroid hormone chemistry.chemical_element Calcium Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Renal Dialysis medicine Humans Hypocalcaemia Aged Calcium metabolism Aged 80 and over Hyperparathyroidism Hypocalcemia business.industry Biochemistry (medical) Guideline Middle Aged medicine.disease Surgery 030104 developmental biology chemistry Kidney Failure Chronic Female Hemodialysis business Blood Chemical Analysis Kidney disease |
| Zdroj: | Clinical chemistry. 62(11) |
| ISSN: | 1530-8561 |
| Popis: | To the Editor: Hemodialysis patients are exposed to high amounts of phosphate and citrate, causing hypocalcaemia and hyperparathyroidism (1). These perturbations have a substantial role in extravascular calcifications causing cardiovascular disease and bone abnormalities. The Kidney Disease: Improving Global Outcomes (KDIGO)1 work group developed a clinical practice guideline on mineral and bone disorders and have advised frequent measurement of calcium, phosphorus, and parathyroid hormone (PTH) (1). Ideally, ionized calcium is measured, but for practical reasons adjusted calcium formulas are broadly used in the clinic. Therapeutic decisions depend on calcium status, in addition to PTH concentrations and clinical aspects (1). Until now, the adequacy of only a few formulas for calculating calcium values in hemodialysis patients has been evaluated. Here, results of the 3 best-performing formulas and the classic modified Orrell from a comprehensive evaluation of 24 formulas are presented. Medline was searched using search terms related to formulas for calculating calcium. Ninety-one blood samples for routine control laboratory measurement from 56 hemodialysis patients were collected. The inclusion criterion was the availability of control panel samples for hemodialysis. Exclusion criteria were interference due to hemolysis, icteria … |
| Databáze: | OpenAIRE |
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