A gut microbial factor modulates locomotor behavior in Drosophila
| Autor: | Zsuzsa Márka, Szabolcs Marka, Catherine E. Schretter, Sarkis K. Mazmanian, Sulabha Argade, Imre Bartos, Jost Vielmetter |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Xylose isomerase Central nervous system Levilactobacillus brevis Sensory system Carbohydrate metabolism Motor Activity Article 03 medical and health sciences 0302 clinical medicine Neural Pathways medicine Animals Germ-Free Life Symbiosis Drosophila Octopamine Aldose-Ketose Isomerases Neurons Multidisciplinary biology biology.organism_classification Cell biology Anti-Bacterial Agents Gastrointestinal Microbiome 030104 developmental biology Nociception medicine.anatomical_structure Drosophila melanogaster Carbohydrate Metabolism Octopamine (neurotransmitter) Female 030217 neurology & neurosurgery Locomotion |
| Zdroj: | Nature |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | While research into the biology of animal behaviour has primarily focused on the central nervous system, cues from peripheral tissues and the environment have been implicated in brain development and function1. There is emerging evidence that bidirectional communication between the gut and the brain affects behaviours including anxiety, cognition, nociception and social interaction1-9. Coordinated locomotor behaviour is critical for the survival and propagation of animals, and is regulated by internal and external sensory inputs10,11. However, little is known about how the gut microbiome influences host locomotion, or the molecular and cellular mechanisms involved. Here we report that germ-free status or antibiotic treatment results in hyperactive locomotor behaviour in the fruit fly Drosophila melanogaster. Increased walking speed and daily activity in the absence of a gut microbiome are rescued by mono-colonization with specific bacteria, including the fly commensal Lactobacillus brevis. The bacterial enzyme xylose isomerase from L. brevis recapitulates the locomotor effects of microbial colonization by modulating sugar metabolism in flies. Notably, thermogenetic activation of octopaminergic neurons or exogenous administration of octopamine, the invertebrate counterpart of noradrenaline, abrogates the effects of xylose isomerase on Drosophila locomotion. These findings reveal a previously unappreciated role for the gut microbiome in modulating locomotion, and identify octopaminergic neurons as mediators of peripheral microbial cues that regulate motor behaviour in animals. |
| Databáze: | OpenAIRE |
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