Differences in Capacity of High-Density Lipoprotein Cholesterol Efflux Between Patients With Systemic Lupus Erythematosus and Rheumatoid Arthritis
| Autor: | Beatriz Tejera-Segura, Federico Díaz-González, Estefanía Armas-González, Miguel A. González-Gay, Juan Carlos Quevedo-Abeledo, José David Machado, Laura de Armas-Rillo, Iván Ferraz-Amaro, Hiurma Sánchez-Pérez |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Apolipoprotein B Biología Population Inflammation Artritis reumatoide Lipoproteínas Gastroenterology Arthritis Rheumatoid 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Rheumatology immune system diseases Internal medicine medicine Humans Lupus Erythematosus Systemic education skin and connective tissue diseases Sistema cardiovascular 030203 arthritis & rheumatology education.field_of_study medicine.diagnostic_test biology Lupus eritematoso discoide Cholesterol business.industry Cholesterol HDL Middle Aged medicine.disease Cross-Sectional Studies chemistry Spain Rheumatoid arthritis Apolipoprotein B-100 biology.protein cardiovascular system Female lipids (amino acids peptides and proteins) medicine.symptom Lipid profile business Biomarkers Lipoprotein |
| Popis: | Objective: Cholesterol efflux capacity (CEC) is the ability of high-density lipoprotein (HDL) cholesterol to accept cholesterol from macrophages. Lipid profiles and CEC appear to be altered in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) due to disease activity and inflammation. CEC has been linked to cardiovascular events in the general population and to subclinical atherosclerosis in SLE and RA patients. The aim of this study was to establish whether CEC varies between patients with SLE and those with RA. Methods: The study encompassed 460 individuals (195 SLE patients and 265 patients with RA). CEC (using an in vitro assay) and concentrations of lipoprotein serum were assessed in both populations. A multivariable regression analysis was performed to study whether CEC differs between SLE patients and RA patients. Results: Comparison of lipid patterns revealed that patients with RA have lower HDL cholesterol and higher apolipoprotein B serum levels than SLE patients. CEC was downregulated in SLE patients compared to patients with RA (β -12 [95% confidence interval -13, -10], P < 0.001). It occurred independently of traditional cardiovascular risk factors, statin use, disease-related data, and other variations in the lipid profile related to the diseases. Conclusion: Patients with RA have a more proatherogenic lipid pattern compared to those with SLE. However, CEC seems to be more damaged in SLE patients than in RA patients. Sin financiación 5.178 JCR (2021) Q2, 12/34 Rheumatology 1.566 SJR (2021) Q1, 7/61 Rheumatology No data IDR 2021 UEC |
| Databáze: | OpenAIRE |
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