Protein arginine methylation: an emerging regulator of the cell cycle
Autor: | Sabine C. Piller, Anita E. Raposo |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
p53 Methyltransferase Arginine DNA repair Review Biochemistry lcsh:RC254-282 03 medical and health sciences Cyclin D1 lcsh:QH573-671 Molecular Biology Cancer biology lcsh:Cytology Retinoblastoma protein Cell Biology Methylation Cell cycle lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cell biology Protein arginine methylation 030104 developmental biology biology.protein Signal transduction Cell cycle regulation |
Zdroj: | Cell Division Cell Division, Vol 13, Iss 1, Pp 1-16 (2018) |
ISSN: | 1747-1028 |
Popis: | Protein arginine methylation is a common post-translational modification where a methyl group is added onto arginine residues of a protein to alter detection by its binding partners or regulate its activity. It is known to be involved in many biological processes, such as regulation of signal transduction, transcription, facilitation of protein–protein interactions, RNA splicing and transport. The enzymes responsible for arginine methylation, protein arginine methyltransferases (PRMTs), have been shown to methylate or associate with important regulatory proteins of the cell cycle and DNA damage repair pathways, such as cyclin D1, p53, p21 and the retinoblastoma protein. Overexpression of PRMTs resulting in aberrant methylation patterns in cancers often correlates with poor recovery prognosis. This indicates that protein arginine methylation is also an important regulator of the cell cycle, and consequently a target for cancer regulation. The effect of protein arginine methylation on the cell cycle and how this emerging key player of cell cycle regulation may be used in therapeutic strategies for cancer are the focus of this review. |
Databáze: | OpenAIRE |
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