Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment
| Autor: | Steven J Street, Catherine M. Milte, Natalie Parletta, Karen A. Sullivan, Jonathan D. Buckley, Peter R. C. Howe, Andrew P. Hills |
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| Přispěvatelé: | Street, Steven John, Parletta, Natalie, Milte, Catherine Margaret, Sullivan, Karen, Hills, Andrew P, Buckley, Jonathan, Howe, Peter |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Reduced risk medicine.medical_specialty Aging Erythrocytes Docosahexaenoic Acids Physical activity Increased physical activity physical activity Motor Activity Developmental psychology mild cognitive impairment Internal medicine Surveys and Questionnaires Fatty Acids Omega-3 medicine Humans Cognitive Dysfunction Cognitive impairment Aged chemistry.chemical_classification Aged 80 and over EPA Eicosapentaenoic acid DHA Psychiatry and Mental health Endocrinology Cross-Sectional Studies chemistry Eicosapentaenoic Acid Ageing Docosahexaenoic acid ageing Dietary Supplements Female Geriatrics and Gerontology Pshychiatric Mental Health Psychology Gerontology Polyunsaturated fatty acid |
| Popis: | Objectives: To evaluate relationships between self-reported physical activity, proportions of long-chain omega-3 polyunsaturated fatty acids (LCn3) in erythrocyte content (percentage of total fatty acids) and risk of mild cognitive impairment (MCI) in older adults. Method: A cross-sectional study was conducted. Community-dwelling male and female (n = 84) participants over the age of 65 years with and without MCI were tested for erythrocyte proportions of the LCn3s eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Physical activity was measured using a validated questionnaire. Results: The interaction between erythrocyte EPA, but not DHA, and increased physical activity was associated with increased odds of a non-MCI classification. Conclusion: An interaction between physical activity and erythrocyte EPA content (percentage of fatty acids) significantly predicted MCI status in older adults. Randomised control trials are needed to examine the potential for supplementation with EPA in combination with increased physical activity to mitigate the risk of MCI in ageing adults Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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