The effect of tetracycline on levels of oral contraceptives
| Autor: | Howard A. Zacur, Ana A. Murphy, Patricia Charache, Ronald T. Burkman |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Adolescent medicine.drug_class Tetracycline media_common.quotation_subject Population Antibiotics Tetracycline 500 MG Physiology Ethinyl Estradiol Internal medicine Follicular phase Humans Medicine Ingestion education Dermatologic disorders Menstrual cycle media_common education.field_of_study business.industry Osmolar Concentration Obstetrics and Gynecology General Medicine Middle Aged Endocrinology Clinical research Contraceptive use Pharmacodynamics Female Norethindrone business hormones hormone substitutes and hormone antagonists Contraceptives Oral medicine.drug |
| Zdroj: | International Journal of Gynecology & Obstetrics. 36:259-259 |
| ISSN: | 0020-7292 |
| DOI: | 10.1016/0020-7292(91)90731-j |
| Popis: | Despite the widespread use of tetracycline for treatment of dermatologic disorders and sexually transmitted diseases, the pharmacodynamics of oral contraceptive use in the presence of tetracycline has not been studied. Seven normal women ingested an oral contraceptive containing ethinyl estradiol 35 micrograms and norethindrone 1 mg in the follicular phase of the menstrual cycle. On day 0 baseline ethinyl estradiol and norethindrone levels were obtained at 0, 1/2, 3/4, 1, 2, 4, 12, and 24 hours after oral contraceptive administration. On day 1 tetracycline 500 mg was given orally every 6 hours while the oral contraceptive was continued. Tetracycline, ethinyl estradiol, and norethindrone levels were determined at the same time intervals as on day 0. Oral contraceptive and tetracycline were continued for up to 10 days, and additional concentrations of ethinyl estradiol, norethindrone, and tetracycline were determined between days 5 and 10. Four additional normal women ingested tetracycline for 5 to 10 days. Tetracycline levels were determined at the time intervals noted above on day 1 and days 5 to 10. No significant decrease in plasma ethinyl estradiol or norethindrone concentration was seen with either short-term (24 hours) or long-term (5 to 10 days) ingestion of tetracycline. Similarly, levels of tetracycline do not significantly decrease with ingestion of a low-dose oral contraceptive. |
| Databáze: | OpenAIRE |
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