2 cases of reversible liver lesion induced by valproate
| Autor: | Finn Boesen, Jens Thygesen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Pathology medicine.diagnostic_test Liver toxicity business.industry Liver Diseases Valproic Acid General Medicine Gastroenterology Liver Neurology Liver lesion Liver tissue Liver biopsy Internal medicine medicine Humans Female lipids (amino acids peptides and proteins) Neurology (clinical) Chemical and Drug Induced Liver Injury Complication business Aged |
| Zdroj: | Acta Neurologica Scandinavica. 66:396-399 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1982.tb06862.x |
| Popis: | Valproate (VPA)-induced hepatic affection is a rare complication. 2 such cases are described in the present study, the first a 24-year-old woman developing liver lesion due to VPA treatment, and the second a 73-year-old woman developing liver affection most probably due to VPA treatment. Both cases were reversible. The latter represents the oldest patient ever reported to suffer VPA-induced reversible liver lesion. Liver biopsy showed liver tissue with drug-induced changes. In order to prevent the development of irreversible liver toxicity, it is important to instruct the patient about the sympoms of VPA-induced liver toxicity and stop the treatment if necessary. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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