Seroprevalence of Toxoplasma gondii, Rubella virus and Cytomegalovirus among pregnant women and the importance of avidity assays
| Autor: | Güliz Doğan, Pınar Şamlıoğlu, Sevgi Yılmaz Hancı, Mümtaz Cem Şirin, Nisel Yilmaz, Yeşer Karaca Derici, Neval Ağuş, Arzu Bayram |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Adolescent Congenital cytomegalovirus infection Antibody Affinity Immunoglobulins Cytomegalovirus Toxoplasma gondii lcsh:Medicine chemical and pharmacologic phenomena medicine.disease_cause Rubella Serology 03 medical and health sciences Young Adult 0302 clinical medicine Pregnancy parasitic diseases medicine Seroprevalence Humans Avidity 030212 general & internal medicine Pregnancy Complications Infectious Retrospective Studies biology seroprevalence business.industry lcsh:R Rubella virus General Medicine Middle Aged medicine.disease biology.organism_classification Virology 030104 developmental biology Cross-Sectional Studies Immunoglobulin M Immunology biology.protein Original Article Female business Toxoplasma |
| Zdroj: | Saudi Medical Journal, Vol 38, Iss 7, Pp 727-732 (2017) Saudi Medical Journal |
| ISSN: | 1658-3175 0379-5284 |
| Popis: | Objectives : To determine the seroprevalence of Toxoplasma gondii (T. gondii), Rubella virus, and Cytomegalovirus (CMV) among pregnant women in Izmir, Turkey. Methods : Medical records of pregnant women attending Izmir Tepecik Training and Research Hospital, Izmir, Turkey between January 2014 and January 2016 were analyzed in this retrospective cross-sectional study. The 7513 T. gondii IgM/IgG results, 7189 Rubella IgM/IgG results, 906 CMV IgM/IgG results and 146 avidity test results were evaluated. Specific IgM and IgG antibodies were detected by an automated chemiluminescent enzyme immunoassay method. Immunoglobulin G avidity tests were performed using a multiparametric immunoassay system. Results : The rates of IgG positivity for T. gondii was 32.3%, Rubella virus 93.5%, and CMV 98.9%. Immunoglobulin M antibodies were found to be positive in 138 (1.9%) cases for T. gondii, 88 (1.2%) cases for Rubella, and 14 (1.5%) cases for CMV. Avidity tests were ordered from 146 of 218 patients who were found both IgM and IgG positive. Among 146 patients, 6 patients had a low avidity index (all for T. gondii), 11 patients showed borderline avidity, and 129 patients revealed high avidity. Conclusion : In our region, whereas the rates of IgG positivity for Rubella and CMV are high, most pregnant women were susceptible to T. gondii infections. In order to enhance the reliability of the serological diagnosis, avidity tests should be performed in all IgM positivities detected together with IgG positivity. Saudi Med J 2017; Vol. 38 (7): 727-732 doi: 10.15537/smj.2017.7.18182 How to cite this article: Sirin MC, Agus N, Yilmaz N, Bayram A, Derici YK, Samlioglu P, et al. Seroprevalence of Toxoplasma gondii, Rubella virus and Cytomegalovirus among pregnant women and the importance of avidity assays. Saudi Med J . 2017 Jul;38(7):727-732. doi: 10.15537/smj.2017.7.18182. |
| Databáze: | OpenAIRE |
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