| Autor: |
Shashank Shekhar, Vincent S. Chan, Rodger F. Henry, José G. Napolitano, Eric M. Phillips, Lynette A. Smyth |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
The Journal of organic chemistry. 81(3) |
| ISSN: |
1520-6904 |
| Popis: |
A novel method for Pd-catalyzed triflination of aryl and heteroaryl triflates using NaSO2CF3 as the nucleophile is described. The combination of Pd2(dba)3 and RockPhos formed the most effective catalyst. A broad range of functional groups and heteroaromatic compounds were tolerated under the neutral reaction conditions. The order of reactivity ArOTf ≥ ArCl ≥ ArBr is consistent with transmetalation being a slow step of the reaction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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