Biogenesis of zinc storage granules in Drosophila melanogaster
| Autor: | Samuel M. Webb, Beatriz Osorio, Thomas Kroll, Abraham Rosas-Arellano, Fanis Missirlis, Carlos Tejeda-Guzmán, Martha Barajas-Aceves |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Malpighian tubule system Physiology chemistry.chemical_element Zinc Aquatic Science Malpighian Tubules 03 medical and health sciences Organelle Animals Drosophila Proteins Molecular Biology Ecology Evolution Behavior and Systematics biology Granule (cell biology) Transporter biology.organism_classification Cell biology 030104 developmental biology Drosophila melanogaster chemistry Insect Science Animal Science and Zoology Female Lysosomes Biogenesis Drosophila Protein Research Article |
| Popis: | Membrane transporters and sequestration mechanisms concentrate metal ions differentially into discrete subcellular microenvironments for usage in protein cofactors, signaling, storage, or excretion. Here we identify zinc storage granules as the insect's major zinc reservoir in principle Malpighian tubule epithelial cells of Drosophila melanogaster. The concerted action of Adaptor Protein-3, Rab32, HOPS and BLOC complexes as well as of the white-scarlet (ABCG2-like) and ZnT35C (ZnT2/ZnT3/ZnT8-like) transporters is required for zinc storage granule biogenesis. Due to lysosome related organelle defects caused by mutations in the homologous human genes, patients with Hermansky-Pudlak syndrome may lack zinc granules in beta pancreatic cells, intestinal paneth cells and presynaptic vesicles of hippocampal mossy fibers. |
| Databáze: | OpenAIRE |
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