Spectrum of Hemoglobinopathies Among the Primitive Tribes
| Autor: | Mahrukh Wadia, Kumar S. Ashokan, Yazdi M. Italia, Rajni Kaul, Dipika Mohanty, Vasantha Muthuswamy, Kanjaksha Ghosh, Dipty Jain, Malay B. Mukherjee, Roshan B. Colah, Guru Prasad Chottray, Deepak Kumar Shukla |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Hemoglobin s
Health plan Traditional medicine business.industry Anemia Hemoglobin Sickle Public Health Environmental and Occupational Health Ethnic group India medicine.disease Hemoglobinopathies Hemoglobinopathy Gene Frequency Population Groups Humans Medicine Statistical analysis business Allele frequency Chromatography High Pressure Liquid Regional differences Demography |
| Zdroj: | Asia Pacific Journal of Public Health. 27:NP562-NP571 |
| ISSN: | 1941-2479 1010-5395 |
| DOI: | 10.1177/1010539513480231 |
| Popis: | We evaluated the spectrum of hemoglobinopathies among the primitive tribal groups from 4 states in India. A total of 15 200 individuals from 14 primitive tribal groups were studied by automated high-performance liquid chromatography. The hemoglobin S (HbS) allele frequency varied from 0.011 to 0.120 and the β-thalassemia allele frequency from 0.005 to 0.024. It is interesting to note that a very high HbS allele frequency was observed among the Dravidian (0.060-0.120) and Indo-European (0.060-0.076) as compared with Austro-Asiatic (0.011-0.022) speaking tribal groups. Although statistical analysis of the data did not show any ethnic differences within the states, regional differences were observed between the states for both HbS and β-thalassemia traits. HbS was found to be the most common hemoglobinopathy followed by β-thalassemia. A health plan for identifying sickle-cell homozygotes in the neonatal period with proper medical intervention is desirable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|