Electrochemotherapy in Skin Malignancies of Head and Neck Cancer Patients: Clinical Efficacy and Aesthetic Benefits
| Autor: | Antonio Bonadies, Ettore Bertozzi, Flavio Andrea Govoni, Emilia Migliano, Renzo Cristiani |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Electrochemotherapy Skin Neoplasms Scars Kaplan-Meier Estimate Cohort Studies 0302 clinical medicine Quality of life Clinical efficacy Aged 80 and over Academic Medical Centers General Medicine Middle Aged Treatment Outcome Italy Head and Neck Neoplasms RL1-803 030220 oncology & carcinogenesis aesthetics Carcinoma Squamous Cell Female medicine.symptom medicine.medical_specialty Esthetics cosmetic outcome Dermatology Risk Assessment Disease-Free Survival Cicatrix 03 medical and health sciences Deformity medicine Humans In patient scar assessment scale Aged Retrospective Studies Chi-Square Distribution business.industry head and neck skin cancer Head and neck cancer medicine.disease Survival Analysis Surgery 030104 developmental biology Quality of Life Skin cancer business Follow-Up Studies |
| Zdroj: | Acta Dermato-Venereologica, Vol 99, Iss 13, Pp 1246-1252 (2019) |
| ISSN: | 1651-2057 |
| Popis: | Skin malignancies of the head and neck inflict significant structural, functional, and cosmetic burdens upon those affected. We retrospectively addressed electrochemotherapy anti-tumour efficacy in head and neck skin cancer patients who were not suitable for standard treatments. Scars' physical characteristics and aesthetics were evaluated using validated scar assessment scales. Among 33 treated patients, 82% experienced a complete tumour response while 18% experienced a partial response. At a median time period of 7 months, 96% of the evaluated scars came close to resembling the normal surrounding skin showing excellent results in terms of restoration to original condition with no deformity and/or distortion and in terms of preservation of functionality, such as oral competence and eye protection. Electrochemotherapy is an effective local anticancer procedure for cutaneous tumours. In the treatment of skin malignancies of the head and neck, especially in non-surgical cases, in the elderly and in patients declining surgery, electrochemotherapy may represent a valid alternative to standard management. |
| Databáze: | OpenAIRE |
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