The development of the method for the determination of terbinafine in cat’s plasma and hair

Autor:	Marinka Drobnič-Košorok, Nevenka Kožuh Eržen, Jernej Kužner
Rok vydání:	2000
Předmět:	Detection limit Reproducibility CATS Chromatography biology Physiology Chemistry Clinical Biochemistry Drug efficiency Human physiology Pharmacology biology.organism_classification Physiology (medical) medicine Terbinafine Sample preparation Microsporum canis medicine.drug
Zdroj:	Pflügers Archiv - European Journal of Physiology. 440:R168-R170
ISSN:	1432-2013 0031-6768
DOI:	10.1007/s004240000050
Popis:	Clinical investigations of terbinafine indicate its high treatment activity against infections by several dermatophytes. Its efficiency was tested also in the treatment of microsporosis in cats. The distribution of terbinafine in cat's plasma and hair is important for the identification of the drug efficiency. A fast and reliable reversed-phase high performance liquid chromatographic method with appropriate sample preparation has been developed. Reliability, good reproducibility and low detection limit (LOD 0.25 ng/ml) of the method enable determination of terbinafine in hair and also in plasma of cats infected with Microsporum canis treated by Lamisil tablets.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05131e48c8b61cc5467ea3bf3533c9c https://doi.org/10.1007/s004240000050 Zobrazit plný text záznamu Full text from SpringerLink